Mocetinostat (MGCD0103) is a potent and isotype-selective inhibitor of histone deacetylases (HDACs). In cell-free assays, Mocetinostat (MGCD0103) exhibited most potent inhibition against human HDAC1 (IC50 = 0.15 ?M) and also has inhibitory activity against HDAC2, HDAC3, and HDAC11, with IC50 va..

Price: $169.00

Trichostatin A (TSA) is a potent histone deacetylase (HDAC) inhibitor. It inhibits HDAC 1, 2, 3, 6, 10, 11 at IC50s of less than 10 nM, with over 300-fold selectivity against class IIa HDACs.[1&91; TSA affects DNA replication and gene expression by inhibiting HDAC activity and therefore altering t..

Price: $129.00

TMP195 is the most potent and selective class IIa HDAC inhibitor identified to date, with IC50s of 59 nM, 60 nM, 26 nM and 15 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively. It has over 100-fold selectivity targeting other HDACs (IC50s>10 µM). TMP195 has an unprecedented zinc-bindin..

Price: $159.00

TMP269 is a highly potent and selective class IIa HDAC inhibitor identified, with IC50s of 126 nM, 80 nM, 36 nM and 19 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively. TMP269 has an unprecedented metal-binding group, trifluoromethyloxadiazole (TFMO). The co-crystal structure of TMP 269 and HD..

Price: $139.00

PCI-34051 is a indole-based hydroxamic acid inhibitor of HDAC-8 with an IC50 of 10 nM. It is at least 200-fold selective over other HDAC isoforms with micromolar IC50s of 4, >50, >50, 2.9, and 13 for HDAC-1, HDAC-2, HDAC-3, HDAC-6, and HDAC-10. [1&91; PCI-34051 induces caspase-dependent apop..

Price: $129.00

Vorinostat (SAHA) is a potent inhibitor of Classes I and II histone deacetylases (HDACs) that works by chelating Zinc ions found in the active site of HDACs. Vorinostat's inhibition of HDAC activity results in the accumulation of acetylated histones and acetylated proteins, including transcript..

Price: $59.00

CUDC-907 is a orally-available, synergistic dual inhibitor of class I PI3K enzymes and class I and II HDAC enzymes. Its inhibition profile against PI3Ka, PI3Kb, and PI3Kd, is 19, 54, and 39 nM, respectively, while HDAC activity is 1.7, 5.0, 1.8, 27, and2.8 nM for HDAC1, HDAC2, HDAC3, HDAC6, and..

Price: $159.00

ACY-1215 (Rocilinostat) is an orally-available, hydroxamic acid-based, selective inhibitor of HDAC6 and HDAC8 with IC50 values of 5 nM and 100 nM, respectively. ACY-1215 is12-, 10-, and 11-fold less active against HDAC1, HDAC2, and HDAC3, respecitvely, and has minimal activity (IC50 > 1 uM) ..

Price: $149.00

Pyroxamide is a potent histone deacetylase (HDAC) inhibitor with IC50 of 100nM. Pyroxamide induced terminal differentiation in murine erythroleukemia (MEL) cells, and inhibited the growth by cell cycle arrest or apoptosis in a variety of tumor cells^1-4. An accumulation of acetylated ..

Price: $159.00

LBH589, a hydroxamate analog, is a broad-spectrum HDAC inhibitor. It has been shown to increase acetylation of core histones (H3 and H4) and nonhistone proteins (alpha-tublin, HSP90), leading to the modulation of gene expression (p21, FOXO3A, GADD45A, aromatase, etc) and protein activity involv..

Price: $129.00