VX-809 (Lumacaftor) is a small molecular corrector and rescues folding defects of F508del mutation in cystic fibrosis transmembrane conductance regulator (CFTR). F508del is the most frequent mutation in CFTR gene that leads to cystic fibrosis (CF). VX-809 (Lumacaftor) directly binds to the pock..

Price: $169.00

VX-770 (Ivacaftor) is a CFTR potentiator and has been shown to potentiate normal CFTR, as well as CFTR with G551D and F508-del mutations. Ivacaftor directly binds to the ion channel, causes conformation change and open the ion channel to improve chloride transportation. In primary cultured huma..

Price: $169.00

Ambrisentan is a propanoic acid??based, orally-available, endothelin receptor type A-receptor antagonist for the once-daily treatment of pulmonary arterial hypertension (PAH). It has >4000-fold selectivity for the type A receptor over type B receptor. Studies indicate that Ambrisentan has a ..

Price: $89.00

BIBF1120 (Vargatef, Nintedanib) is an oxindole-based, orally-available triple kinase inhibitor targeting the angiogenesis factors VEGF, PDGF, and FGF. It inhibits VEGFR, PDGFR, and FGFR at potency ranges of 13-34, 59-65, and 37-108 nM. [1&91; Kinase panel studies show that it also inhibits Flt-3, ..

Price: $129.00

PTC-124 (Ataluren) is an oxadiazole-based, orally available agent deisgned to selectively promote ribosomal readhtrough of premature stop codons, but not normal termination codons. [1&91; The minimal concentration of PTC124 showing observable readthrough was 0.01 - 0.1 uM (2.8 - 28 ng/ml), while m..

Price: $79.00

ICG-001 is a small-molecule antagonist of b-catenin/TCF-mediated transcription (IC50 = 3 uM) and specifically downregulates the expression of a subset of b-catenin/TCF-responsive genes. ICG-001 binds specifically to cyclic AMP response element-binding protein (CBP), therby disrupting interactio..

Price: $129.00