Latanoprost is a potent and selective agonist of Prostaglandin F receptor (FP). It activates FP, a G-protein coupled receptor (GPCR), with EC50 of 10 nM, and with at least 500-fold selectivty over other Prostaglandin receptors. (1) Upon activation, FP promotes the decrease of intraocular pressu..

Price: $139.00

GSK1292263 is a novel GPR119 receptor agonist used for the treatment of type 2 diabetes. The predicted EC50 of GSK1292263 against GPR119 in vitro is at the nanomolar range. (1) The GPR119 receptor is a GPCR which is selectively expressed on pancreatic beta cells and intestinal enteroendocrine c..

Price: $189.00

Ambrisentan is a propanoic acid??based, orally-available, endothelin receptor type A-receptor antagonist for the once-daily treatment of pulmonary arterial hypertension (PAH). It has >4000-fold selectivity for the type A receptor over type B receptor. Studies indicate that Ambrisentan has a ..

Price: $89.00

NVP-AUY954 is an orally-available, benzothiazole-based, monoselective agonist of the sphingosine-1-phosphate receptor 1 (S1P1) intended for the treatment of human autoimmune mediated inflammatory neuropathies. Along with EC50 potency of 1.2 nM, NVP-AUY954 has at least 280-fold selectivity for S..

Price: $149.00

SYN115 (Tozadenant) is a orally-available, benzothiazole-based, antagonist of the Adenosine A2A receptor for the treatment of Parkinson's disease and other CNS-related conditions. SYN115 is being pursued as a monotherapy as well as in combination with L-dopamine and is being studied for its pot..

Price: $169.00

Prucalopride is an orally-available, dibenzofuran-based, enterokinetic agonist of the human serotonin 5-HT4a and 5-HT4b receptor isoforms with Ki estimates of 3 nM and 8 nM, respectively. It has modest selectivity over the human D4 receptor (2.3 uM), mouse 5-HT3 receptor (3.7 uM) and human s1 r..

Price: $129.00

MK0524, a fused indole-based antagonist of prostaglandin D2 (DP), has a Ki binding affinity of 0.57 nM and a Kd dissociation constant of 0.03 nM. With the exception of the TxA2 receptor (Ki = 2.95 nM), MK0524 has excellent selectivity over a number of other prostanoid receptors (EP family, FP, ..

Price: $149.00

Alcaftadine, a imidazobenzazepine-based antagonist of the histamine receptors, has a pKi of 8.5 and 5.8 for the H1 receptor and H4 receptors, respectively. Additionally, Alcaftadine shows higher affinity for the H2 receptor than ketotifen. [1&91;

In support of its potent anti-inflammato..

Price: $149.00

TAK-875 is an orally-available, benzofuran-based, agonist of GPR40 for the potential treament of Type 2 diabetes mellitus, with an human EC50 of 0.014 uM in a FLIPR assay. It has high selectivity over GPR41, GPR43, and GPR120, with EC50s all greater than 10 uM. [1&91; Oral dosing (0.3-3 mg/kg) of ..

Price: $159.00

CGS21680, an A2A adenosine receptor agonist, is under investigation in various inflammation models for potential novel therapies. For example, CGS21680 possesses an anti-inflammatory effect during chronic inflammation and lessens the tissue damage associated with collagen-induced arthritis. [1&91;..

Price: $129.00