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S3I-201 (NSC74859) | Stat3 activity inhibitor

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Catalog #:

Product Description

S3I-201 (NSC74859) is a cell-permeable, amidosalicylic acid based small molecule that inhibits Stat3 activity with IC50 of 86 µM1. S3I-201 binds to the Stat3-SH2 domain and prevents its dimerization, inhibiting stat3 phosphorylation, translocation and Stat3-dependent transcription activities. S31-201 preferentially inhibits growth and induces apoptosis in tumor cells that contain persistently activated stat31. In addition, S3I-201 has been shown to retard stat3-dependent tumor growth in human breast tumor xenograft models, and to impair VZV infection of skin xenografts in vivo1,2,3.

Technical information:

Chemical Formula:   C16H15NO7 S
CAS #:   501919-59-1
Molecular Weight:   365.36
Purity:   >98%
Appearance:   Off white solid
Chemical Name:   2-Hydroxy-4-[[[(4-methylphenyl)sulfonyloxy]acetyl]amino]-benzoic acid
Solubility:   Up to 50 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


1. Siddiquee K. et al. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7391-6.
2. Lin L, et al. The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling. Oncogene, 2009, 28(7), 961-972.
3. Sen N, et al. Signal transducer and activator of transcription 3 (STAT3) and survivin induction by varicella-zoster virus promote replication and skin pathogenesis. Proc Natl Acad Sci U S A, 2012, 109(2), 600-605.

Other Information:

Product Specification (pdf)
MSDS (pdf)

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