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SF1670 | PTEN inhibitor

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Price:
$219.00
Catalog #:
C7316-2s
Quantity:


Product Description

SF1670 is a selective PTEN inhibitor (IC50=2 µM). As PTEN-mTOR pathway is critical for controlling the regenerative capacity of corticospinal neurons, PTEN deletion or its inhibitor enhances the regenerative ability of adult corticospinal neurons. Pretreatment with SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model.

Product Citation


Technical information:

Chemical Formula:   C19H17NO3
CAS #:   345630-40-2
Molecular Weight:   307.34
Purity:   >98%
Appearance:   Purple solid
Chemical Name:   N-(9,10-dioxo-9,10-dihydrophenanthren-2-yl)pivalamide
Solubility:   Up to 100 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Garlich, Joseph et al. Preparation of (heteroaryl) amides and hydrazides as inhibitors of phosphatase located on chromosome 10 (PTEN). PCT Int. Appl. (2005), WO 2005097119.
2. Kai Liu, et al. PTEN deletion enhances the regenerative ability of adult corticospinal neurons. Nature Neuroscience (2010), 13(9), 1075-1081.
3. Yitang Li, et al. Pre-treatment with PTEN inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. Blood. 2011;117(24):6702-13.

Other Information:

Product Specification (pdf)
MSDS (pdf)

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