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SYN115 | Adenosine A(2a) receptor antagonist

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Price:
$169.00
Catalog #:
C7911-5
Quantity:


Product Description

SYN115 (Tozadenant) is a orally-available, benzothiazole-based, antagonist of the Adenosine A2A receptor for the treatment of Parkinson's disease and other CNS-related conditions. SYN115 is being pursued as a monotherapy as well as in combination with L-dopamine and is being studied for its potential neuroprotective effects. [1]

Animal studies with SYN115 support beliefs that A2A antagonists reduce Parkinson's symptoms by reducing the inhibitory output of the basal ganglia indirect pathway. Using Cerebral Blood Flow (CBF) as a pharmacodynamic parameter, studies have shown that SYN115 induces a significant decrease in thalamic CBF, consistent with the deactivation of the indirect pathway. [2]


Technical information:

Chemical Formula:   C19H26N4O4S
CAS #:   870070-55-6
Molecular Weight:   406.5
Purity:   > 98%
Appearance:   White
Chemical Name:   4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide
Solubility:   Up to 50 mM in DMSO
Synonyms:   SYN115, SYN-115

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Biotie Therapies website (2013-04-24)
2. Black et al., Quantification of Indirect Pathway Inhibition by the Adenosine A2a Antagonist SYN115 in Parkinson Disease. Black et al., J. Neurosci. 2010, 30(48), 16284-16292. Pubmed ID: 21123574

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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