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VX-680 (Tozasertib) | Aurora A inhibitor

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Product Description

VX-680 (Tozasertib) is a small molecule Aurora kinase inhibitor (Aurora-A ~0.6nM, Aurora-B ~18nM, Aurora-C ~4.6nM). VX-680 inhibits cell cycle progression, induces apoptosis and blocks tumor growth in varieties of in vivo xenograft models, including leukemia, colon and pancreatic tumors.

Technical information:

Chemical Formula:   C23H28N8OS
CAS #:   639089-54-6
Molecular Weight:   464.59
Purity:   >98%
Appearance:   Light yellow solid
Chemical Name:   N-(4-((4-((5-methyl-1H-pyrazol-3-yl)amino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl)thio)phenyl)cyclopropanecarboxamide
Solubility:   Up to 100 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


1. Elizabeth A Harrington, et al. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nature Medicine 2004;10, 262 – 267.
2. Marumoto T, Zhang D, Saya H. Aurora-A - a guardian of poles. Nat Rev Cancer. 2005; 5(1):42-50.

Other Information:

Product Specification (pdf)
MSDS (pdf)

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