KHS101 binds to TACC3, which is a structural component of the centrosome and mitotic spindle apparatus, prevents its ability to sequester ARNT2 in the cytoplasm. A study performed in rats showed KHS101 is a small molecule that can induce neural differentiation by inhibiting NPC maintenance, while also stabilizing proneurogenesis transcriptional pathways. KHS101 can accelerate neural differentiation from the progenitor pool by blocking self-renewal.
Technical information:
| Chemical Formula: | C18H21N5S | |
| CAS #: | 1262770-73-9 | |
| Molecular Weight: | 339.46 | |
| Purity: | >98% | |
| Appearance: | White solid | |
| Chemical Name: | N4-isobutyl-N2-((2-phenylthiazol-4-yl)methyl)pyrimidine-2,4-diamine | |
| Solubility: | Up to 100 mM in DMSO |
Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.
Reference:
| 1. | Wurdak, S. Zhu, K.H. Min, L. Aimone, L.L. Lairson, J. Watson, G. Chopiuk, J. Demas, B. Charette and R. Halder et al., A small molecule accelerates neuronal differentiation in the adult rat, Proc. Natl. Acad. Sci. USA 107 (2010), pp. 16542–16547. |
Other Information:
Product Specification (pdf)
MSDS (pdf)