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7,8-Dihydroxyflavone

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Price:
$69.00
Catalog #:
C7181-10
Quantity:


Product Description

7,8-Dihydroxyflavone binds to the extracellular domain of tyrosine kinase receptor B (Kd = 320 nM) and activate the receptor activity. It inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro and in vivo. Administration of 7,8-dihydroxyflavone to mice activated TrkB in the brain, inhibited kainic acid-induced toxicity, decreased infarct volumes in stroke in a TrkB-dependent manner, and was neuroprotective in an animal model of Parkinson disease. It also reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's Disease.


Technical information:

Chemical Formula:   C15H10O4
CAS #:   38183-03-8
Molecular Weight:   254.24
Purity:   >98%
Appearance:   White solid
Chemical Name:   7,8-dihydroxy-2-phenyl-4H-chromen-4-one
Solubility:   Up to 100 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Sung-Wuk Jang et al. A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone.  Proc.Natl.Acad.Sci.USA. 2010; 107 268.
2. Latha Devi et al. 7,8-Dihydroxyflavone, a Small-Molecule TrkB Agonist, Reverses Memory Deficits and BACE1 Elevation in a Mouse Model of Alzheimer's Disease. Neuropsychopharmacology advance online publication 7 September 2011.
3. Zhang R et al. Preventive effect of 7,8-dihydroxyflavone against oxidative stress induced genotoxicity. Biol Pharm Bull. 2009;32(2):166-71
4. Raul Andero et al. Effect of 7,8-Dihydroxyflavone, a Small-Molecule TrkB Agonist, on Emotional Learning. Am J Psychiatry 2011; 168:163-172.

Other Information:

Product Specification (pdf)
MSDS (pdf)

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