A83-01 is a selective inhibitor of ALK5 (12nM), ALK4 (45nM), and ALK7 (7.5 nM), and only weakly inhibits ALK1, 2, 3, and 6. It inhibits the TGF-β-induced epithelial-to-mesenchymal transition (EMT) via the inhibition of Smad2 phosphorylation. A83-01 has been used to generate rat and human iPS cells towards a mouse ES cell like self-renewal state.
Technical information:
| Chemical Formula: | C25H19N5S | |
| CAS #: | 909910-43-6 | |
| Molecular Weight: | 421.52 | |
| Purity: | >98% | |
| Appearance: | Pale yellow solid | |
| Chemical Name: | 3-(6-methylpyridin-2-yl)-N-phenyl-4-(quinolin-4-yl)-1H-pyrazole-1-carbothioamide | |
| Solubility: | Up to 100 mM in DMSO |
Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.
Reference:
| 1. | Tojo M, Hamashima Y, et al. The ALK-5 inhibitor A-83-01 inhibits smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. Cancer Science (2005), 96(11), 791-800. |
| 2. | Li W, Wei W, et al. Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell Stem Cell (2009), 4(1), 16-19. |
Other Information:
Product Specification (pdf)
MSDS (pdf)
