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BAF312

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Price:
$169.00
Catalog #:
C2233
Quantity:


Product Description

BAF312 (Siponimod) is a potent sphingosine-1 receptor (S1P-R) modulator selectively targeting S1P1 and S1P5 receptors [1]. BAF312 reduces inflammation by sequestering lymphocytes in lymphoid tissues [2]. BAF312 also binds its receptors on neurons, astrocytes and oligodendrocytes and present neuroprotective effects [3]. Siponimod showed neuroprotective effects in the CNS of encephalomyelitis mice and organotypic cultures. is currently under investigation in a clinical trial in secondary progressive multiple sclerosis patients [4].


Technical information:

Chemical Formula:   C29H35F3N2O3
CAS #:   1230487-00-9
Molecular Weight:   516.6
Purity:   > 98%
Appearance:   White
Chemical Name:   (E)-1-(4-(1-(((4-cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)azetidine-3-carboxylic acid
Solubility:   Up to 200mM in DMSO
Synonyms:   Siponimod

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder or DMSO solution at -20oC desiccated.


Reference:

1. Pan S, et al. Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator. ACS Med Chem Lett. 2013; 4(3): 333–337. Pubmed ID: 24900670
2. Hundehege P, et al. The next-generation sphingosine-1 receptor modulator BAF312 (siponimod) improves cortical network functionality in focal autoimmune encephalomyelitis. Neural Regen Res 2019; 14:1950-60 Pubmed ID: 31290453
3. Gentile A, et al. Siponimod (BAF312) prevents synaptic neurodegeneration in experimental multiple sclerosis. J Neuroinflammation. 2016; 13(1): 207. Pubmed ID: 27566665
4. Kappos L, et al. Safety and Efficacy of Siponimod (BAF312) in Patients With Relapsing-Remitting Multiple Sclerosis Dose-Blinded, Randomized Extension of the Phase 2 BOLD Study. JAMA Neurol 2016;73(9):1089-98. Pubmed ID: 31290453

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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