BAPTA-AM is a rationally-designed relative of the well-known chelator EGTA. BAPTA-AM and its analogs have a 100-fold greater affinity for Ca2+ over Mg2+, are resistant to pH changes, and are faster in uptake and release of Ca2+. [1] BAPTA-AM, the acetic acid methyl ester analog of the original BAPTA, offers greater cell permeability and is known to inactivate protein kinase C.
Technical information:
| Chemical Formula: | C34H40N2O18 | |
| CAS #: | 126150-97-8 | |
| Molecular Weight: | 764.68 | |
| Purity: | > 98% | |
| Appearance: | White | |
| Chemical Name: | 1,2-Bis(2-aminophenoxy)ethane-N,N,N?,N?-tetraacetic acid tetrakis(acetoxymethyl ester) | |
| Solubility: | Up to 22 mM in DMSO | |
| Synonyms: | BAPTA-AM, BAPTA, AM |
Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.
Reference:
| 1. | Tsien, R., New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. Biochemistry, 1980, 19, 2396-2404. Pubmed ID: 6770893 |
Other Information:
Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.