DAPT is a γ-secretase inhibitor and indirectly an inhibitor of Notch, a γ-secretase substrate. Since the Notch pathway is involved in the development of both the nervous system and pancreas, DAPT may be useful in modulating Notch activity in embryonic stem cell differentiation studies.
Technical information:
| Chemical Formula: | C23H26F2N2O4 | |
| CAS #: | 208255-80-5 | |
| Molecular Weight: | 432.46 | |
| Purity: | >98% | |
| Appearance: | White solid | |
| Chemical Name: | N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenylglycine-1,1-dimethylethyl ester | |
| Solubility: | Up to 35 mM in DMSO |
Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.
Reference:
| 1. | Dovey, HF. et al. Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. J Neurochem. 2001 Jan;76(1):173-81. |
| 2. | Crawford, T. and Roelink, H. (2007) The Notch Response inhibitor DAPT enhances neuronal differentiation in embryonic stem cell-derived embryoid bodies independently of Sonic Hedgehog Signaling. Dev Dyn. 2007 Mar;236(3):886-92. |
Other Information:
Product Specification (pdf)
MSDS (pdf)
