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DAPT | γ-secretase inhibitor

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Catalog #:

Product Description

DAPT is a γ-secretase inhibitor and indirectly an inhibitor of Notch, a γ-secretase substrate. Since the Notch pathway is involved in the development of both the nervous system and pancreas, DAPT may be useful in modulating Notch activity in embryonic stem cell differentiation studies.

Technical information:

Chemical Formula:   C23H26F2N2O4
CAS #:   208255-80-5
Molecular Weight:   432.46
Purity:   >98%
Appearance:   White solid
Chemical Name:   N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenylglycine-1,1-dimethylethyl ester
Solubility:   Up to 35 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


1. Dovey, HF. et al. Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. J Neurochem. 2001 Jan;76(1):173-81.
2. Crawford, T. and Roelink, H. (2007) The Notch Response inhibitor DAPT enhances neuronal differentiation in embryonic stem cell-derived embryoid bodies independently of Sonic Hedgehog Signaling. Dev Dyn. 2007 Mar;236(3):886-92.

Other Information:

Product Specification (pdf)
MSDS (pdf)

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