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Doripenem | Broad spectrum antibiotic

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Product Description

Doripenem is a parenterally-administred antimicrobial of the carbapenem family, with minimum inhibitory concentrations (MIC) of 0.25 ug/mL in Pseudomonas aeruginosa and Escherichia coli. [1] Similar to other b-lactam antibiotics, Doripenem forms stable acyl-enzymes with pencillin-binding proteins, leading to the their inactivation and eventual cell wall rupture.

Doripenem is approved for the treatment of complicated intra-abdominal infections and urinary tract infections. It is active against gram-positive, gram-negative, and anaerobic organisms, and is stable against a wide variety of b-lactamases and renal dehydropeptidases. [2, 3]

Technical information:

Chemical Formula:   C15H24N4O6S2.H2O
CAS #:   148016-81-3
Molecular Weight:   438.52
Purity:   > 99%
Appearance:   White
Chemical Name:   1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-[[(3S,5S)-5-[[(aminosulfonyl)amino]methyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-, hydrate
Solubility:   Up to 75 mM in DMSO
Synonyms:   Doripenem, Doribax

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


1. Paterson et al., Doripenem. Clin. Infect. Dis. 2009, 49(2), 291-298. Pubmed ID: 19527173
2. Matthews et al., Doripenem monohydrate, a broad-spectrum carbapenem antibiotic. Clin. Therapeutics, 2009, 31(1), 42-63. Pubmed ID: 19243706
3. Greer et al., Doripenem (Doribax): the newest addition to the carbapenems. Proceedings, Baylor University Medical Center, 2008, 21(3), 337-341. Pubmed ID: 18628935

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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