Loading... Please wait...

Our Newsletter

Mocetinostat (MGCD0103)

  • Mocetinostat 200x200
  • Mocetinostat 600-600
Catalog #:

Product Description

Mocetinostat (MGCD0103) is a potent and isotype-selective inhibitor of histone deacetylases (HDACs). In cell-free assays, Mocetinostat (MGCD0103) exhibited most potent inhibition against human HDAC1 (IC50 = 0.15 ?M) and also has inhibitory activity against HDAC2, HDAC3, and HDAC11, with IC50 values ranged 0.3 to 1.7 ?M. No activity was showed on HDACs 4-8. [1] Mocetinostat (MGCD0103) exhibited potent inhibition activity in proliferation of human cancer cell lines, both in cell-based assay and in human tumor xenografts in nude mice. [1]
Mocetinostat (MGCD0103) has been evaluated in Phase II clinical trials in patients with metastatic leiomyosarcoma [2] and Hodgkin??s lymphoma [3]."

Technical information:

Chemical Formula:   C23H20N6O
CAS #:   726169-73-9
Molecular Weight:   396.44
Purity:   > 98%
Appearance:   Off-white
Chemical Name:   N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide
Solubility:   Up to 10 mM in DMSO
Synonyms:   Mocetinostat, MGCD0103, MG0103

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder or DMSO solution at -20oC desiccated.


1. Fournel M, et al. MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo. Mol Cancer Ther. 2008; 7(4):759-68 Pubmed ID: 18413790

SARC018: A Study of Mocetinostat and Gemcitabine in Patients With Metastatic Leiomyosarcoma. clinicaltrials.gov/NCT02303262 

3. Mocetinostat (MGCD0103) Plus Brentuximab Vedotin (SGN-35) in Patients With Relapsed or Refractory Hodgkin Lymphoma. clinicaltrials.gov/NCT02429375 

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

Write your own product review

Product Reviews

This product hasn't received any reviews yet. Be the first to review this product!

Add to Wish List

Click the button below to add the Mocetinostat (MGCD0103) to your wish list.

You Recently Viewed...