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ONO-7475 

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Price:
$219.00
Catalog #:
C6667
Quantity:


Product Description

ONO-7475 is a potent inhibitor of Anexelekto(Axl)/MER tyrosine kinase with IC50 at nM range for both AXL and MER.  AXL has been implicated in diverse tumor-promoting processes such as proliferation, migration, invasion, survival, and apoptosis, and therefore considered a promising druggable target to overcome drug resistance for acute myeloid leukemia, pancreatic cancer [2], lung cancer [3], as well as breast cancer [3].  ONO-7475 sensitizes and suppresses the emergence of tolerant cells to the initial EGFR-TKIs, osimertinib or dacomitinib, in AXL-overexpressing EGFR-mutated NSCLC cells, suggesting that ONO-7475 and osimertinib is a highly potent combination for initial treatment of NSCLC.


Technical information:

Chemical Formula:  

C32H26N4O6

CAS #:   1646839-59-9
Molecular Weight:   562.57
Purity:   > 98%
Appearance:   Off-White
Chemical Name:   N-(5-((6,7-dimethoxyquinolin-4-yl)oxy)pyridin-2-yl)-2,5-dioxo-1-phenyl-1,2,5,6,7,8-hexahydroquinoline-3-carboxamide
Solubility:   Up to 150 mM in DMSO
Synonyms:   ONO 7475, ONO7475

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder or DMSO solution at -20oC desiccated.


Reference:

1. Post SM, et al. AXL/Mertk Inhibitor ONO-7475 Potently Synergizes with BCL2 Inhibitor ABT-199, Overcomes ABT-199 Resistance Mechanisms, and Kills FLT3 ITD AML Cells. Blood 2019; 134 (Supplement_1): 2550. Pubmed ID: doi.org/10.1182/blood-2019-128626
2. Du W, et al.  Does Axl have potential as a therapeutic target in pancreatic cancer?  Expert Opin Ther Targets 2018; 22(11):955-966. Pubmed ID: 30244621
3. Okura N, et al. ONO-7475, a Novel AXL Inhibitor, Suppresses the Adaptive Resistance to Initial EGFR-TKI Treatment in EGFR-Mutated Non–Small Cell Lung Cancer.  Clin Cancer Res 2020;26:2244–56. Pubmed ID: 31953310
   

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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