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GW501516 | PPARδ agonist

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Catalog #:

Product Description

GW501516 is a selective PPARd agonist with a Ki affinity of 1.1 nM in a human binding assay. In a cell-based transfection assay, GW501516 induces expression of GAL4-responsive reporter gene at an EC50 of 1.2 nM. At doses up to 1 uM, GW501516 does not promote adipocyte differentiation, bind to RXRa, or have activity toward other nuclear or non-nuclear receptors. (1) GW501516 incrases expression of the reverse cholesterol transporter ATP-binding cassette A1 and induces apolipoprotein A1-specific cholesterol efflux. (1)

GW501516 is also reported to be a PPARb agonist with anti-inflammatory activity and decreases IFN-g-induced upregulation of TNF-a and iNOS. Concurrently, GW501516 increase IL-6 mRNA expression. (2)

Technical information:

Chemical Formula:   C21H18F3NO3S2
CAS #:   317318-70-0
Molecular Weight:   453.5
Purity:   > 98%
Appearance:   white
Chemical Name:   2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methylthio)phenoxy)acetic acid
Solubility:   Up to 22 mM in DMSO
Synonyms:   GW501516, GW-501,516, GW1516, GSK-516, Endurobol

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


1. Oliver et al., A selective peroxisome proliferator-activated receptor d agonist promotes reverse cholesterol transport. Proc. Nat'l. Acad. Sci. 2001, 98(9), 5306-5311. Pubmed ID: 11309497
2. Defaux et al., Effects of the PPAR-b agonist GW501516 in an in vitro model of brain inflammation and antibody-induced demyelination. J. Neuroinflammation, 2009, 6, 15-27. Pubmed ID: 19422681

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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