LY294002 is a highly selective phosphatidylinositol 3-kinase (PI3K) inhibitor, with no inhibitory activities against EGF receptor kinase, MAP kinases, PKC, PI 4-kinase, S6 kinase and c-Src. Recent study also showed it inhibits of casein kinase II.
LY294002 inhibits cell proliferation of choroidal melanoma OCM-1 cells. In regulation of murine ES cell self-renewal, LY294002 led to a reduction in the ability of LIF to maintain self-renewal via regulated expression of dominant negative delta-p85. It can also enhance the generation of mouse induced pluripotent stem cells.
Technical information:
| Chemical Formula: | C19H17NO3 | |
| CAS #: | 154447-36-6 | |
| Molecular Weight: | 307.34 | |
| Purity: | >98% | |
| Appearance: | White solid | |
| Chemical Name: | 2-morpholin-4-yl-8-phenylchromen-4-one | |
| Solubility: | Up to 100 mM in DMSO |
Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.
Reference:
| 1. | Vlahos CJ et al. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-4H-1-benzopyran-4-one (LY294002). J Biol Chem. 1994; 269(7):5241-8. |
| 2. | Paline NR et al. Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. J Biol Chem. 2004; 279(46):48063-70. |
| 3. | Chen T et al. Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells. Aging Cell. 2011; 10(5):908-911 |
Other Information:
Product Specification (pdf)
MSDS (pdf)
