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Necrostatin-1 | RIP1 inhibitor

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Product Description

Necrostatin-1 is a specific ATP-competitive allosteric inhibitor (EC50 = 180 nM) of death domain receptor-associated adaptor kinase (RIP1)1. It selectively blocks a specific programmed cell death pathway, necroptosis, which leads to necrosis. While affecting this distinct cell death pathway, Necrostatin-1 does not present any perturbation of the Fas/TNFR triggered canonical apoptosis cascade. Necrostatin-1 inhibits the necrosis-induced RIP1 and RIP3 interactions in vitro2 and reduces ischemic brain injury in a mouse model of stroke3.

Technical information:

Chemical Formula:   C13H13N3OS
CAS #:   4311-88-0
Molecular Weight:   259.33
Purity:   >98%
Appearance:   Light yellow solid
Chemical Name:   5-((1H-indol-3-yl)methyl)-3-methyl-2-thioxoimidazolidin-4-one
Solubility:   Up to 50 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


1. Degterev A., et al. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat. Chem. Biol. (2008), 4:313-321
2. Sun L., et al. Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase. Cell (2012), 148:213-227.
3. Degterev A., et al. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat. Chem. Biol. (2005), 1:112-119

Other Information:

Product Specification (pdf)
MSDS (pdf)

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