Ormetoprim is a diaminopyrimidine-based inhibitor of dihydrofolate reductase, the enzyme responsible for NADPH-dependent reduction of 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate. (1) This inhibition results in the interference in folic acid production. In bacteria, Ormetoprim, weakly antibacterial by itself, can act as a potentiator by cotreatment with sulfadimethoxine, which in turn prevents the formation of folinic acid. (2)
Technical information:
| Chemical Formula: | C14H18N4O2 | |
| CAS #: | 6981-18-6 | |
| Molecular Weight: | 274.32 | |
| Purity: | > 98% | |
| Appearance: | white | |
| Chemical Name: | 2,4-Diamino-5-(6-methylveratryl)pyrimidine | |
| Solubility: | Up to 100 mM in DMSO | |
| Synonyms: | 0 |
Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.
Reference:
| 1. | Manchand et al., Syntheses of Antibacterial 2,4-Diamino-5 benzylpyrimidines. Ormetoprim and Trimethoprim. J. Org. Chem. 1992, 57, 3531-3535. |
| 2. | Boothe, D.M., Sulfonamides and Sulfonamide Combinations, Merck Manuals, March, 2012. |
Other Information:
Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.
