P22077 is a potent and selective USP7 inhibitor. It specifically inhibits deubiquitylating enzyme (DUB) USP7 and the closely related USP47 (at 5µM), but not the other majority of DUBs (at 15-45µM). USP7 has been found to be critical in cancer progression due to its influence on the stability of the tumor suppressor p53. The inhibition of USP7 is predicted to destabilize HDM2 and stabilize p53, and USP7 exerts both p53-dependent and p53-independent effects on controlling cell proliferation and apoptosis.
Technical information:
| Chemical Formula: | C12H7F2NO3S2 | |
| CAS #: | 1247819-59-5 | |
| Molecular Weight: | 315.32 | |
| Purity: > 98% | ||
| Appearance: | White | |
| Chemical Name: | 1-(5-((2,4-difluorophenyl)thio)-4-nitrothiophen-2-yl)ethanone | |
| Solubility: | Up to 50 mM in DMSO | |
| Synonyms: | TMP195 |
Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.
Reference:
| 1. | 1. Mikael Altun et al. Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes. (2011) Chemistry & Biology 18, 1401??1412. |
Other Information:
Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.
