PQ401 is a diarylurea-based inhibitor of IGF-1R, inhibiting autophosphorylation in MCF-7 cells and the IGF-1R isolated kinase domain at IC50s of 12 uM and < 1 uM, respectively. In IGF-1R stimulated MCF-7 cells, PQ401 was more effective at an IC50 of 6 uM. In MCF-7 cells IGF-1-mediated signaling is decreased by way of the Akt antiapoptotic pathway. Prolonged incubation with PQ401 induces a dose-dependent increase in caspase activation. (1)
Technical information:
| Chemical Formula: | C18H16ClN3O2 | |
| CAS #: | 196868-63-0 | |
| Molecular Weight: | 341.79 | |
| Purity: | > 98% | |
| Appearance: | white | |
| Chemical Name: | N-(5-Chloro-2-methoxyphenyl)-N'-(2-methylquinolin-4-yl)urea | |
| Solubility: | Up to 50 mM in DMSO | |
| Synonyms: | PQ401, PQ-401 |
Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.
Reference:
| 1. | Gable et al., Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth. Mol. Cancer Ther. 2006, 5, 1079-1086. Pubmed ID: 16648580 |
Other Information:
Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.
