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PQ401 | IGF-1R inhibitor

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Price:
$99.00
Catalog #:
C7740-5
Quantity:


Product Description

PQ401 is a diarylurea-based inhibitor of IGF-1R, inhibiting autophosphorylation in MCF-7 cells and the IGF-1R isolated kinase domain at IC50s of 12 uM and < 1 uM, respectively. In IGF-1R stimulated MCF-7 cells, PQ401 was more effective at an IC50 of 6 uM. In MCF-7 cells IGF-1-mediated signaling is decreased by way of the Akt antiapoptotic pathway. Prolonged incubation with PQ401 induces a dose-dependent increase in caspase activation. (1)


Technical information:

Chemical Formula:   C18H16ClN3O2
CAS #:   196868-63-0
Molecular Weight:   341.79
Purity:   > 98%
Appearance:   white
Chemical Name:   N-(5-Chloro-2-methoxyphenyl)-N'-(2-methylquinolin-4-yl)urea
Solubility:   Up to 50 mM in DMSO
Synonyms:   PQ401, PQ-401

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Gable et al., Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth. Mol. Cancer Ther. 2006, 5, 1079-1086. Pubmed ID: 16648580

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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