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Pyroxamide | HDAC inhibitor

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Catalog #:

Product Description

Pyroxamide is a potent histone deacetylase (HDAC) inhibitor with IC50 of 100nM. Pyroxamide induced terminal differentiation in murine erythroleukemia (MEL) cells, and inhibited the growth by cell cycle arrest or apoptosis in a variety of tumor cells1-4. An accumulation of acetylated histones and increased levels of p21/WAF1 expression were detected in cancer cells and in prostate xenografts treated with pyroxamide1,2.

Technical information:

Chemical Formula:   C13H19N3O3
CAS #:   382180-17-8
Molecular Weight:   265.31
Purity:   >98%
Appearance:   Off white solid
Chemical Name:   N-Hydroxy-N'-3-pyridinyloctanediamid
Solubility:   Up to 50 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


1. Butler et al. Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase. Clin.Cancer Res. 7 962. (2001)
2. Kutko, MC., et al. Histone deacetylase inhibitors induce growth suppression and cell death in human rhabdomyosarcoma in vitro. Clin Cancer Res. Nov 15;9(15):5749-55.(2003)
3. Kouraklis G, Theocharis S. Histone deacetylase inhibitors and anticancer therapy. Curr Med Chem Anticancer Agents. Jul;2(4):477-84.(2002)
4. Kouraklis G, Theocharis S Histone deacetylase inhibitors: a novel target of anticancer therapy (review). Oncol Rep. Feb;15(2):489-94. (2006)

Other Information:

Product Specification (pdf)
MSDS (pdf)

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