Thiazovivin is a potent ROCK inhibitor. It dramatically improves the survival of hESCs during cell trypsinization manipulation. Thiazovivin in combination with inhibitors of the TGF-β receptor and the MEK pathway improve reprogramming efficiency more than 200-fold.
Technical information:
| Chemical Formula: | C15H13N5OS | |
| CAS #: | 1226056-71-8 | |
| Molecular Weight: | 311.36 | |
| Purity: | >98% | |
| Appearance: | Light brown solid | |
| Chemical Name: | N-Benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide | |
| Solubility: | Up to 100 mM in DMSO |
Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.
Reference:
| 1. | Lin, T., Ambasudhan, R., Yuan, X., Li, W., Hilcove, S., Abujarour, R., Lin, X., Hahm, H., Hao, E., Hayek, A., Ding, S. (2009) A chemical platform for improved induction of human iPSCs. Nature Methods 6, 805 - 808 (2009) |
Other Information:
Product Specification (pdf)
MSDS (pdf)
