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SU5402 is a fibroblast growth factor receptor (FGFR)-specific tyrosine kinase inhibitor with IC50 ~0.03µM. Multiple myeloma studies suggest that SU 5402 inhibits FGFR3 phosphorylation in vitro. SU5402 is also very potent in inhibiting VEGFR, and PDGFR. Research shows that it inhibits embryonic left-right determination and exhibits potent anticancer activity in vitro and in vivo. SU5402 (2µM) with CHIR99021 (3µM) and PD0325901 (0.4µM) have proven to be highly effective for maintaining pluripotency of ESCs.
|Chemical Name:||(Z)-3-(4-methyl-2-((2-oxoindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid|
|Solubility:||Up to 100 mM in DMSO|
Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.
|1.||Sun L., et al. Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases. J Med Chem. 1999;42(25):5120-30|
|2.||Tanaka Y., et al. FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination. Nature. 2005;435(7039):172-7|
|3.||Qi-Long Ying, et al. The ground state of embryonic stem cell self-renewal. Nature 2008; 453, 519–523|