Loading... Please wait...

Categories

Our Newsletter


LY2811376 | BACE inhibitor

  • LY2811376.jpg
  • LY2811376, 400x400px, png
Price:
$169.00
Catalog #:
C5281-5
Quantity:


Product Description

LY-2811376 is a orally-available, non-peptidic inhibitor of hBACE1 with an IC50 of 239 nM. Selectivity of LY-2811376 for BACE1 over BACE2 was found to be 10-fold, and 50-fold or greater over related aspartyl proteases cathepsin D, pepsin, or renin. [1] In APP-overexpressing human embryonic kidney cell lines, LY-2811376 treatment decreased Ab secretion in a concentration-dependent fashion, with an EC50 of ~300 nM. In primary neuronal cultures of PDAPP transgenic mouse, Ab secretion was measured at an EC50 of ~100 nM.

In vivo, LY2811376 inhibits BACE1 activity by concomitantly reducing C99 and sAPPb, the two primary APP cleavage products generated by BACE1.


Technical information:

Chemical Formula:   C15H14F2N4S
CAS #:   1194044-20-6
Molecular Weight:   320.36
Purity:   > 98%
Appearance:   White
Chemical Name:   (S)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine
Solubility:   Up to 50 mM in DMSO
Synonyms:   LY-2811376, LY 2811376, LY2811376

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. May et al., Robust central reduction of amyloid-? in humans with an orally available, non-peptidic ?-secretase inhibitor. J. Neurosci., 2011, 31(46), 16507-16516. Pubmed ID: 22090477

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

Write your own product review

Product Reviews

This product hasn't received any reviews yet. Be the first to review this product!

Add to Wish List

Click the button below to add the LY2811376 | BACE inhibitor to your wish list.

You Recently Viewed...