Loading... Please wait...


Our Newsletter

VX-950 (Telaprevir) | HCV protease inhibitor

  • VX-950 (Telaprevir).jpg
  • VX-950 (Telaprevir), 400x400px, png
Catalog #:

Product Description

VX-950 (Telaprevir) is an orally-available, highly-selective, reversible, peptidomimetic inhibitor of HCV NS3-4A protease with an IC50 of 0.35 uM and IC90 of 0.83 uM in an HCV replicon assay [1, 2] In human fetal hepatocytes with genotype 1a HCV-postive patient serum, VX-950 has an IC50 of 280 uM. [3] VX-950 reduces HCV RNA levels in a time- and dose-dependent manner with IC50s of 0.57, 0.49, 0.21, and 0.14 uM following a 24-, 48-, 72-, and 120-h incubation.

VX-950 forms a covalent, but reversible complex in a slow-on, slow-ff process with a steady-state inhibition constant (Ki) of 7 nM. [3] Excellent efficacy with high liver exposure in an HCV NS3-4A mouse model was observed with VX-950.

Technical information:

Chemical Formula:   C36H53N7O6
CAS #:   402957-28-2
Molecular Weight:   679.85
Purity:   >98%
Appearance:   White
Chemical Name:   (1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)-octahydrocyclopenta[c]pyrrole-1-carboxamide
Solubility:   Up to 100mM in DMSO
Synonyms:   VX-950, VX-950, Telaprevir, Incivek, Incivo

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


1. Lin et al., VX-950, a novel hepatitis C virus (HCV) NS3-4A protease inhibitor, exhibits potent antiviral activities in HCv replicon cells. Antimicrob. Agents Chemother. 2006, 50(5), 1813-1822. Pubmed ID: 16641454
2. Lin et al., Discovery and development of VX-950, a novel, covalent, and reversible inhibitor of hepatitis C virus NS3.4A serine protease. Infectious Disorders: Drug Targets, 2006, 6(1), 3-16. Pubmed ID: 16787300
3. Perni et al., Preclinical profile of VX-950, a potent, selective, and orally bioavailable inhibitor of hepatitis C virus NS3-4A serine protease. Antimicrob. Agents Chemother. 2006, 50(3), 899-909. Pubmed ID: 16495249

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

Write your own product review

Product Reviews

This product hasn't received any reviews yet. Be the first to review this product!

Add to Wish List

Click the button below to add the VX-950 (Telaprevir) | HCV protease inhibitor to your wish list.

You Recently Viewed...