Loading... Please wait...

Categories

Our Newsletter


Rivaroxaban (Xarelto) | Protease Factor Xa inhibitor

  • Rivaroxaban (Xarelto).jpg
  • Rivaroxaban (Xarelto), 400x400px, png
Price:
$169.00
Catalog #:
C7472-5
Quantity:


Product Description

Rivaroxaban is an orally-bioavailable, oxazolidinone-based inhibitor (Ki = 0.4 nM) of factor Xa, the factor in the blood coagulation pathway leading to thrombin generation and clot formation. [1] It is approved for both deep vein thrombosis and pulmonary embolism. It is >10000-fold selective for fXa over other biologically relevant serine proteases. Rivaroxaban inhibits prothrombinase-bound (IC50 = 2.1 nM, and clot-associated factor Xa (IC50 = 75 nM) in a dose-dependent manner. [1]

In vivo, Rivaroxaban inhibits endogenous fXa more potently in human and rabbit plasma (IC50 = 21 nM) than in rat plasma (IC50 = 290 nM). [2] In human plasma, PT and aPTT were doubled at 0.23 and 0.69 uM, respectively.


Technical information:

Chemical Formula:   C19H18ClN3O5S
CAS #:   366789-02-8
Molecular Weight:   435.88
Purity:   >99%
Appearance:   White
Chemical Name:   (S)-5-chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide
Solubility:   Up to 100 mM in DMSO
Synonyms:   Rivaroxaban, Xarelto, BAY-59-7939, BAY 59-7939, BAY59-7939

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Perzborn et al., Rivaroxaban: a new oral factor Xa inhibitor. Arterioscler. Thromb. Vasc. Biol. 2010, 30, 376-381. Pubmed ID: 20139357
2. Perzborn et al., In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939--an oral, direct Factor Xa inhibitor. J. Thromb. Haemost. 2005, 3(3), 514-521. Pubmed ID: 15748242

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

Find Similar Products by Category

Write your own product review

Product Reviews

This product hasn't received any reviews yet. Be the first to review this product!

Add to Wish List

Click the button below to add the Rivaroxaban (Xarelto) | Protease Factor Xa inhibitor to your wish list.

You Recently Viewed...