Loading... Please wait...

Our Newsletter


A-674563 | PKB/Akt inhibitor

  • A-674563.jpg
  • A-674563, 400x400px, png
Price:
$159.00
Catalog #:
C2167-2s
Quantity:


Product Description

A-674563 is a potent and selective PKB/Akt inhibitor with an IC50 of 14 nM. It binds to ATP-binding site of Akt and reduces the phosphorylation of Akt's downstream targets (GSK3α/β, FOXO3, TSC2, mTOR and S6, etc.). A-674563 also inhibits activity of PKA and CDK2 with IC50 of 16 and 46 nM, respectively. A-674563 inhibits proliferation of tumor cells with IC50 of 0.4 µM1.

In STS cells, A-674563 induces Akt pathway blockade that decreases downstream target phosphorylation, and induces G2 cell cycle arrest and apoptosis. In vivo, A-674563 reduces STS xenograft growth2. When given in combination, A-674563 enhanced the efficacy of paclitaxel in a PC-3 xenograft model1.


Technical information:

Chemical Formula:   C22H22N4O
CAS #:   552325-73-2
Molecular Weight:   358.44
Purity:   >98%
Appearance:   White solid
Chemical Name:   (2S)-1-(5-(3-methyl-1H-indazol-5-yl)pyridin-3-yloxy)-3-phenylpropan-2-amine
Solubility:   Up to 100 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Luo Y, et al. Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo. Mol Cancer Ther. 2005. 4(6):977-86. PMID: 15956255
2. Zhu QS, et al. Soft tissue sarcoma cells are highly sensitive to AKT blockade: a role for p53-independent up-regulation of GADD45 alpha. Cancer Res. 2008. 68(8):2895-903. PMID: 18413758

Other Information:

Product Specification (pdf)
MSDS (pdf)

Find Similar Products by Tag

cancer  mTOR  

Find Similar Products by Category

Write your own product review

Product Reviews

This product hasn't received any reviews yet. Be the first to review this product!

Add to Wish List

Click the button below to add the A-674563 | PKB/Akt inhibitor to your wish list.

You Recently Viewed...