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AGI-5198 (IDH-C35) | IDH1 inhibitor

  • AGI-5198 (IDH-C35) (.png)
  • AGI-5198 (IDH-C35) (.jpg)
Catalog #:

Product Description

AGI-5198 (IDH-C35) is a potent and selective isocitrate dehydrogenase 1 (IDH1) inhibitor specifically against R132H/C mutants (mIDH1) with IC50 at 100 nM range. AGI-5198 does not inhibit wild-type IDH1 or any of the examined IDH2 isoforms (IC50 > 100 µM).[1] AGI-5198 inhibits R-2-hydroxyglutarate (R-2HG) production by mIDH1. AGI-5198 also induces demethylation of histone H3K9me3 and expression of genes associated with gliogenic differentiation.

In both in vitro and in vivo studies, AGI-5198 inhibited the growth of glioma cells carrying mutated but not wild type IDH1, yet with no appreciable changes in genome-wide DNA methylation. These data suggest that mIDH1 may promote glioma growth through mechanisms beyond its well-characterized epigenetic effects. AGI-5198 could serve as a very useful chemical tool to probe the mechanism and treatment of mIDH1-carrying tumors

Technical information:

Chemical Formula:   C27H31FN4O2
CAS #:   1355326-35-0
Molecular Weight:   462.56
Purity:   > 98%
Appearance:   White
Chemical Name:   N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-methyl-1H-imidazol-1-yl)acetamido)-2-(o-tolyl)acetamide
Solubility:   Up to 25 mM in DMSO
Synonyms:   AGI-5198, AGI5198, IDH-C35

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder or DMSO solution at -20oC desiccated.


1. Rohle D, et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science. 2013; 340(6132):626-30. Pubmed ID: 23558169

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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