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BSI-201 (Iniparib) | PARP inhibitor

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Price:
$89.00
Catalog #:
C2201-5
Quantity:


Product Description

BSI-201 (Iniparib), a iodonitrobenzamide-based cytotoxic agent, was initially considered to be a PARP inhibitor based on its abillity to inactivate PARP by means of zinc ejection from the zinc finger of the enzyme. [1]

Despite its ability to kill normal and neoplastic cells at high concentrations (>40 uM), further studies revealed that BSI-201 did not selectivly kill homologous-recombination (HR)-deficient cells, sensitize cells to topoisomerase I poisons, or inhibit PARP in situ, as seen with olaparib and veliparib. [2]

Through a battery of enzymatic, cellular, and viability assays, BSI-201 was shown to nonselectively modify cysteine-containing proteins in tumor cells. It is also postulated that the formation of nonspecific adducts can alter stability, activity, and localization, thus inducing apoptosis, stress, cell-cycle perturbation, or DNA damage. [3]


Technical information:

Chemical Formula:   C7H5IN2O3
CAS #:   160003-66-7
Molecular Weight:   292.03
Purity:   > 98%
Appearance:   White
Chemical Name:   4-iodo-3-nitrobenzamide
Solubility:   Up to 100 mM in DMSO
Synonyms:   BSI-201, BSI201, BSI 201, 160003-66-7, Iniparib

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Mendeleyev et al., Potential chemotherapeutic activity of 4-iodo-3-nitrobenzamide. Biochem. Pharmacol. 1995, 50(5), 705-714. Pubmed ID: 7669074
2. Patel et al., Failure of Iniparib to inhibit poly(ADP-Ribose) polymerase in vitro. Clin. Cancer Res. 2012, 18, 1655-1662. Pubmed ID: 22291137
3. Liu et al., Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bonafide PARP inhibitor. Clin. Cancer Res. 2012, 18, 510-523.

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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