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(+)-JQ-1

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Price:
$129.00
Catalog #:
C5701
Quantity:


Product Description

(+)-JQ-1 is a highly potent and selective BET bromodomain BRD2/4 inhibitor that showed activity impairing mouse macrophage inflammatory response [1], activating HIV latency [2], and blocking the BET mediated acetylation and transcriptions of c-Myc [3].  


Technical information:

Chemical Formula:  

C23H25ClN4O2S

CAS #:   1268524-70-4
Molecular Weight:   456.99
Purity:   > 98%
Appearance:   White
Chemical Name:   (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester
Solubility:   Up to 100 mM in DMSO
Synonyms:   JQ1

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder or DMSO solution at -20oC desiccated.


Reference:

1. Anna C, et al.  BET protein function is required for inflammation: Brd2 genetic disruption and BET inhibitor JQ1 impair mouse macrophage inflammatory responses. J Immunol. 2013; 190(7): 3670–3678. Pubmed ID: 23420887
2. Li Z, et al, The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation. Nucleic Acids Res. 2013; 41(1): 277–287. Pubmed ID: 23087374
3. Alqahtani A, et al.  Bromodomain and extra-terminal motif inhibitors: a review of preclinical and clinical advances in cancer therapy.  Future Sci OA. 2019; 5(3): FSO372 Pubmed ID: 30906568
   

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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