Forskolin is a naturally occurring diterpene from the Indian plant, Coleus forskohlii, and works as an activator of adenylate cyclase resulting in an increase in the intracellular concentration of cAMP. Forskolin is used in several differentiation protocols for its ability to potentiate neuron differentiation.
Technical information:
| Chemical Formula: | C22H34O7 | |
| CAS #: | 66428-89-5 | |
| Molecular Weight: | 410.50 | |
| Purity: | >98% | |
| Appearance: | White solid | |
| Chemical Name: | (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldodecahydro-1H-benzo[f]chromen-5-yl acetate | |
| Solubility: | Up to 100 mM in DMSO |
Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.
Reference:
| 1. | Laurenza, A., et al. Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action. Trends Pharm. Sci. (1989) 10: 442-447. |
| 2. | Hedin, L. et al. Forskolin effects on the cAMP system and steroidogenesis in the immature rat ovary. Mol Cell Endocrinol (1983) 33: 69-80. |
| 3. | Son, H. et al. Pairing of forskolin and KCl increases differentiation of immortalized hippocampal neurons in a CREB Serine 133 phosphorylation-dependent and extracellular-regulated protein kinase-independent manner. Neurosci Lett (2001) 308: 37-40. |
| 4. | Palmer, T.D. et al. The adult rat hippocampus contains primordial neural stem cells. Mol Cell Neurosci (1997) 8: 389-404. |
Other Information:
Product Specification (pdf)
MSDS (pdf)
