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PCI-34051 | HDAC8 inhibitor

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Catalog #:

Product Description

PCI-34051 is a indole-based hydroxamic acid inhibitor of HDAC-8 with an IC50 of 10 nM. It is at least 200-fold selective over other HDAC isoforms with micromolar IC50s of 4, >50, >50, 2.9, and 13 for HDAC-1, HDAC-2, HDAC-3, HDAC-6, and HDAC-10. [1] PCI-34051 induces caspase-dependent apoptosis at low micromolar concentrations in cell lines derived from T-cell lymphomas, including Jurkat and HuT78, but is not cytotoxic to other hematopoietic or solid tumor lines. Unlike other unselective or pan-HDAC inhibitors, PCI-34051 does not induce histone or tubulin acetylation.

The unique specificity of PCI-34051 was used to invalidate HDAC-8 as a potential target for reduction or cholesterol accumulation in lysosomal storage organelles (LSOs) of two NPC1 mutant human fibroblast lines. [2]

Technical information:

Chemical Formula:   C17H16N2O3
CAS #:   950762-95-5
Molecular Weight:   296.32
Purity: > 99%
Appearance:   White
Chemical Name:   1-(4-methoxybenzyl)-N-hydroxy-1H-indole-6-carboxamide
Solubility:   Up to 100 mM in DMSO
Synonyms:   PCI-34051, PCI34051

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


1. Balasubramanian et al., A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas, Leukemia, 2008, 22(5), 1026-1034. Pubmed ID: 18256683
2. Pipalia et al., Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts. Proc. Nat. Acad. Sci. 2011, 108(14), 5620-5625. Pubmed ID: 21436030

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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