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PD0332991 | Cdk4/6 inhibitor

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Price:
$129.00
Catalog #:
C7306-5
Quantity:


Product Description

PD0332991 is a highly specific inhibitor of cyclin-dependent kinase 4 (Cdk4) (~0.011 µM) and Cdk6 (~0.016 µM), having no activity against a panel of 36 additional protein kinases. PD0332991 causes elimination of phospho-Rb and the proliferative marker Ki-67 in tumor tissue and downregulation of genes under the transcriptional control of E2F. It has showed significant inhibition in a broad spectrum of human tumor xenografts in vivo.


Technical information:

Chemical Formula:   C24H29N7O2
CAS #:   571190-30-2
Molecular Weight:   447.53
Purity:   >98%
Appearance:   White solid
Chemical Name:   6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one
Solubility:   Up to 100 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Fry DW, et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther. 2004;3(11):1427-38
2. Eline Menu, et al. A Novel Therapeutic Combination Using PD 0332991 and Bortezomib: Study in the 5T33MM Myeloma Model. Cancer Res 2008;68:5519-5523
3. Finn RS, et al. PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro. Breast Cancer Res. 2009;11(5):R77.

Other Information:

Product Specification (pdf)
MSDS (pdf)

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