PS48 is an allosteric small molecule activator of phosphoinositide-dependent protein kinase 1 (PDK1). It binds to the HM/PIF binding pocket instead of the ATP-binding site. PS48 has been used to enhance reprogramming of neonatal human epidermal keratinocytes (NHEKs).
Technical information:
| Chemical Formula: | C17H15ClO2 | |
| CAS #: | 1180678-32-7 | |
| Molecular Weight: | 286.75 | |
| Purity: | >98% | |
| Appearance: | White solid | |
| Chemical Name: | 5-(4-Chloro-phenyl)-3-phenyl-pent-2-enoic acid | |
| Solubility: | Up to 100 mM in DMSO |
Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.
Reference:
| 1. | Hindie et al. Structure and allosteric effects of low-molecular- weight activators on the protein kinase PDK1. Nature Chem Biol. (2009) 5: 758-764. |
| 2. | Bobkova et al. Discovery of PDK1 Kinase Inhibitors with a novel mechanism of action by ultra-high throughput screening. J Biol Chem. (2010) 285: 18838-18846. |
| 3. | Zhu et al. Reprogramming of Human Primary Somatic Cells by Oct4 and Chemical Compounds. Cell Stem Cell. (2010) 7 (6)651-655. |
Other Information:
Product Specification (pdf)
MSDS (pdf)
