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TMC125 (Etravirine) | HIV-1 reverse transcriptase inhibitor

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Product Description

TMC125 is a nonnucleoside reverse transcriptase inhibitor with an EC50 of 1.4 to 4.3 nM for wild-type HIV-1. Additionally, TMC125 is highly potent against a wide range of single-mutant and double-mutant NNRTI-resistant HIV-1 strains, including L100I, K103N, Y181C, and L100I+K103N, at EC50s of 3, 1, 7, and 19 nM, respectively. (1)

TMC125 is believed to have a high barrier to development of resistance in vitro based on multiplicity of infection experiments which confirm a profile distinct from other reverse transcriptase inhibitors. (2)

Technical information:

Chemical Formula:   C20H15BrN6O
CAS #:   269055-15-4
Molecular Weight:   435.28
Purity:   > 98%
Appearance:   white
Chemical Name:   4-((6-amino-5-bromo-2-((4-cyanophenyl)amino)pyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile
Solubility:   Up to 50 mM in DMSO
Synonyms:   TMC125, TMC-125, Etravirine

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


1. Andries et al., TMC125, a Novel Next-Generation Nonnucleoside Reverse Transcriptase Inhibitor Active against Nonnucleoside Reverse Transcriptase Inhibitor-Resistant Human Immunodeficiency Virus Type 1. Antimicrob. Agents Chemother. 2004, 48(12), 4680-4686. Pubmed ID: 15561844
2. Vingerhoets et al., TMC125 Displays a High Genetic Barrier to the Development of Resistance: Evidence from In Vitro Selection Experiments. J. Virol. 2005, 79(20), 12773-12782. Pubmed ID: 16188980

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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