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Trichostatin A (TSA) | HDAC inhibitor

  • Trichostatin-A (TSA) (.png)
  • Trichostatin-A (TSA) (.jpg)
Price:
$129.00
Catalog #:
C8742-2s
Quantity:


Product Description

Trichostatin A (TSA) is a potent histone deacetylase (HDAC) inhibitor. It inhibits HDAC 1, 2, 3, 6, 10, 11 at IC50s of less than 10 nM, with over 300-fold selectivity against class IIa HDACs.[1] TSA affects DNA replication and gene expression by inhibiting HDAC activity and therefore altering the histone modifications and access of DNA inside chromatin.

Trichostatin A induces apoptosis and cell growth arrest at both G and G/M phases. As HDACs are overexpressed in many cancer types, TSA is widely used to probe the tumorigenesis mechanism targeting HDAC.[2] Trichostatin A was found to prevent the differentiation of embryonic stem cell,[3] while TSA treatment increased functional characteristics of human ESC/iPSC-derived cardiomyocytes.[4]


Technical information:

Chemical Formula:   C17H22N2O3
CAS #:   58880-19-6
Molecular Weight:   302.37
Purity:   > 98%
Appearance:   Brown
Chemical Name:   (R,2E,4E)-6-(4-(dimethylamino)benzoyl)-N-hydroxy-4-methylhepta-2,4-dienamide
Solubility:   Up to 50 mM in DMSO
Synonyms:   Trichostatin A, TSA

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder or DMSO solution at -20oC desiccated.


Reference:

1. Lobera M, et al. Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group. Nat Chem Biol. 2013; 9(5):319-25. Pubmed ID: 23524983
2. Timmermann S, et al. Histone acetylation and disease. Cell Mol Life Sci. 2001; 58(5-6):728-36. Review Pubmed ID: 11437234
3. Lee JH, et al. Histone deacetylase activity is required for embryonic stem cell differentiation. Genesis. 2004; 38(1):32-8. Pubmed ID: 14755802
4. Otsuji TG, et al. Dynamic link between histone H3 acetylation and an increase in the functional characteristics of human ESC/iPSC-derived cardiomyocytes. PLoS One. 2012; 7(9):e45010 Pubmed ID: 11437234

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.












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