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Wnt-C59 was first disclosed in patent WO2010101849 as a potent Wnt signaling modulator. It has IC50 less than 0.11 nM in Wnt-Luc reporter assay for Wnt pathway inhibition. In the study, Wnt-C59 prevents palmitylation of Wnt proteins by Porcupine (Porcn, a membrane-bound O-acyltransferase), thereby blocking Wnt secretion and activity, similar to Wnt inhibitors IWP-2, IWP-3 and IWP-4. But Wnt-C59 is more potent and selective, and has better chemical/physical properties, suitable for in vitro/in vivo studies.
|Appearance:||Pale Yellow solid|
|Solubility:||Up to 50 mM in DMSO|
Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.
|1.||Dai Chen et al. (N-(HETERO)ARYL,2-(HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS. PCT WO/2010/101849.|
|2.||Chen B, Dodge ME, Tang W, Lu J, Ma Z, Fan CW, Wei S, Hao W, Kilgore J, Williams NS, Roth MG, Amatruda JF, Chen C, Lum L. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol. 2009;5(2):100-7.|