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IWP-3 | Wnt inhibitor

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Catalog #:

Product Description

IWP-3 is a selective small molecule wnt inhibitor, prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, thereby blocking Wnt secretion and activity1. It blocks phosphorylation of the Lrp6 receptor and accumulation of both Dvl2 and β-catenin. It has an IC50 of 40 nM which is 100 folds less potent than Wnt-C59, but it can still efficiently promote cardiomyocyte differentiation from human ESCs.

Technical information:

Chemical Formula:   C22H17FN4O2S3
CAS #:   687561-60-0
Molecular Weight:   484.59
Purity:   >98%
Appearance:   Light yellow solid
Chemical Name:   2-(3-(4-fluorophenyl)-3,4,6,7-tetrahydro-4-oxothieno[3,2-d]pyrimidin-2-ylthio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide
Solubility:   Up to 100 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


1. Baozhi Chen, et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nature Chemical Biology (2009); 5(2), 100-107.
2. Willems E, et al. Small-Molecule Inhibitors of the Wnt Pathway Potently Promote Cardiomyocytes From Human Embryonic Stem Cell-Derived Mesoderm. Circ Res. 2011

Other Information:

Product Specification (pdf)
MSDS (pdf)

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