Loading... Please wait...

Categories

Our Newsletter


IWP-3 | Wnt inhibitor

  • IWP-3.jpg
  • IWP-3, 400x400px, png
Price:
$109.00
Catalog #:
C4971-2s
Quantity:


Product Description

IWP-3 is a selective small molecule wnt inhibitor, prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, thereby blocking Wnt secretion and activity1. It blocks phosphorylation of the Lrp6 receptor and accumulation of both Dvl2 and β-catenin. It has an IC50 of 40 nM which is 100 folds less potent than Wnt-C59, but it can still efficiently promote cardiomyocyte differentiation from human ESCs.


Technical information:

Chemical Formula:   C22H17FN4O2S3
CAS #:   687561-60-0
Molecular Weight:   484.59
Purity:   >98%
Appearance:   Light yellow solid
Chemical Name:   2-(3-(4-fluorophenyl)-3,4,6,7-tetrahydro-4-oxothieno[3,2-d]pyrimidin-2-ylthio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide
Solubility:   Up to 100 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Baozhi Chen, et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nature Chemical Biology (2009); 5(2), 100-107.
2. Willems E, et al. Small-Molecule Inhibitors of the Wnt Pathway Potently Promote Cardiomyocytes From Human Embryonic Stem Cell-Derived Mesoderm. Circ Res. 2011

Other Information:

Product Specification (pdf)
MSDS (pdf)

Find Similar Products by Category

Write your own product review

Product Reviews

This product hasn't received any reviews yet. Be the first to review this product!

Add to Wish List

Click the button below to add the IWP-3 | Wnt inhibitor to your wish list.

You Recently Viewed...