Loading... Please wait...

Our Newsletter

53AH | Wnt pathway inhibitor

  • 53AH.jpg
  • 53AH, 400x400px, png
Catalog #:

Product Description

53AH is a selective Wnt pathway inhibitor. It is a cyclohexyl analog of IWR-1 with defined centers of chirality. In the Wnt assay, the 53AH has 5-fold greater potency in Wnt inhibition. Compared to IWR-1, 53AH is more potent at promoting stem cell differentiation into cardiomyocytes. The increase in Wnt pathway inhibition potency correlates with a 1.4-fold increase in cardiogenesis. 53AH possesses superior physicochemical properties compared to IWR-1 including improved water solubility and significantly increased chemical stability at pH = 7.4 and low cytotoxicity. Accordingly, 53AH is significantly more robust for long-term cell-based experiments and potency in cardiogenesis because of its superior chemical properties.

Technical information:

Chemical Formula:   C26H28N2O3
CAS #:   N/A
Molecular Weight:   416.51
Purity:   >98%
Appearance:   Off white solid
Chemical Name:   (1R,4r)-4-((2s,3aR,4R,7S,7aS)-1,3-dioxooctahydro-1H-4,7-methanoinden-2-yl)-N-(quinolin-8-yl)cyclohexanecarboxamide
Solubility:   Up to 50 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


1. Willems E, et al, Small-molecule inhibitors of the Wnt pathway potently promote cardiomyocytes from human embryonic stem cell-derived mesoderm. Circ Res. 2011;109(4):360-4. PMID: 21737789

Other Information:

Product Specification (pdf)
MSDS (pdf)

Find Similar Products by Category

Write your own product review

Product Reviews

This product hasn't received any reviews yet. Be the first to review this product!

Add to Wish List

Click the button below to add the 53AH | Wnt pathway inhibitor to your wish list.

You Recently Viewed...