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53AH | Wnt pathway inhibitor

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Price:
$219.00
Catalog #:
C5324-2s
Quantity:


Product Description

53AH is a selective Wnt pathway inhibitor. It is a cyclohexyl analog of IWR-1 with defined centers of chirality. In the Wnt assay, the 53AH has 5-fold greater potency in Wnt inhibition. Compared to IWR-1, 53AH is more potent at promoting stem cell differentiation into cardiomyocytes. The increase in Wnt pathway inhibition potency correlates with a 1.4-fold increase in cardiogenesis. 53AH possesses superior physicochemical properties compared to IWR-1 including improved water solubility and significantly increased chemical stability at pH = 7.4 and low cytotoxicity. Accordingly, 53AH is significantly more robust for long-term cell-based experiments and potency in cardiogenesis because of its superior chemical properties.


Technical information:

Chemical Formula:   C26H28N2O3
CAS #:   N/A
Molecular Weight:   416.51
Purity:   >98%
Appearance:   Off white solid
Chemical Name:   (1R,4r)-4-((2s,3aR,4R,7S,7aS)-1,3-dioxooctahydro-1H-4,7-methanoinden-2-yl)-N-(quinolin-8-yl)cyclohexanecarboxamide
Solubility:   Up to 50 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Willems E, et al, Small-molecule inhibitors of the Wnt pathway potently promote cardiomyocytes from human embryonic stem cell-derived mesoderm. Circ Res. 2011;109(4):360-4. PMID: 21737789

Other Information:

Product Specification (pdf)
MSDS (pdf)

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