Loading... Please wait...

Categories

Our Newsletter


AZD5438 | CDK 1/2/9 inhibitor

  • AZD5438.jpg
  • AZD5438, 400x400px, png

Price:
$129.00
SKU:
C2543-5
Quantity:
Buy in bulk and save

Product Description

AZD5438 is an orally-bioavailable imidazole-pyrimidine inhibitor of cyclin dependent kinase (CDK) 1, 2, and 9 at IC50s of 16, 6, and 20 nM, respectively. In vitro AZD5438 showed significant antiproliferative activity in human tumor cell lines with IC50s in the range of 0.2-1.7 uM, inhibiting phosphorylation of CDK substrates pRb, nucleolin, protein phosphatase 1a, and RNA polymerase II carboxylate-terminus. AZD5438 blocks cell cycling at the G2-M, S, and G1 phases and maintains suppression of biomarkers such as phospho-pRbSer249/Thr252 for up to 16h following a single oral dose in SW620 cells. [1]

Technical information:

Chemical Formula:   C18H21N5O2S
CAS #:   602306-29-6
Molecular Weight:   371.46
Purity:   >98%
Appearance:   Pale Orange
Chemical Name:   4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(methylsulfonyl)phenyl)pyrimidin-2-amine
Solubility:   Up to 100 mM in DMSO
Synonyms:   AZD-5438, AZD 5438, AZD5438

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.

Reference:

1. Byth et al., AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts. Mol. Cancer. Ther. 2009, 8, 1856-1866. Pubmed ID: 19509270

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

Add to Wish List

Click the button below to add the AZD5438 | CDK 1/2/9 inhibitor to your wish list.

You Recently Viewed...