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Product Description

IWP-2 is one of the original Inhibitors of Wnt production compounds that targets Porcupine (Porcn), an acyltransferase catalyzing the palmitoylation lipidation of Wnt proteins [1]. IWP2 specifically inhibits Porcn acyltransferase activity and consequently blocks Wnt protein secretion and does not block general protein secretion of cellular responses mediated by the Hh and Notch proteins [2].

Technical information:

Chemical Formula:   C22H18N4O2S3
CAS #:   686770-61-6
Molecular Weight:   466.6
Purity:   > 98%
Appearance:   Off-white
Chemical Name:   N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
Solubility:   Up to 5 mM in DMSO
Synonyms:   0

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder or DMSO solution at -20oC desiccated.


1. Chen B, et al. Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol 2009; 5: 100–107. Pubmed ID: 19125156
2. Dodge ME, et al. Diverse Chemical Scaffolds Support Direct Inhibition of the Membrane-bound O-Acyltransferase Porcupine. J Biol Chem 2012; 287: 23246-23254 Pubmed ID: 22593577

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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