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Strontium ranelate | Promote osteoblast differentiation

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Catalog #:

Product Description

Strontium ranelate (Protelos), a strontium (II) salt of ranelic acid, is an agent for the treatment of osteoarthritis and osteoporosis. Classified as a dual-action bone agent (DABA), strontium ranelate is unique in that it can simultaneously inhibit bone resorption and stimulate bone formation. [1]

More specifically, strontium ranelate increases in vitro osteoblast differentiation from progenitors, as well as osteoblast-induced osteoclastogenesis both in vitro and in vivo. Regarding bone-antiresorbing mechanisms, strontium ranelate decreases osteoclast differentiation and activity, while increasing their apoptosis. [2]

Technical information:

Chemical Formula:   C12H6N2O8SSr2
CAS #:   135459-87-9
Molecular Weight:   513.49
Purity:   >98%
Appearance:   White
Chemical Name:   5-[Bis(carboxymethyl)amino]-2-carboxy-4-cyano-3-thiopheneacetic Acid Strontium Salt
Solubility:   Up to 22 mM in DMSO
Synonyms:   Strontium ranelate, Protelos, Osseor, Ranelic acid distrontium salt

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


1. Ireland, G., Protos: The first dual-action bone agent for osteoporosis, JEMDSA, 2006, 11(1), 35.
2. Fonseca et al., Mechanism of action of strontium ranelate: what are the facts? Clin. Cases. Mineral Bone Metabol. 2010, 7(1), 17-18. Pubmed ID: 22461285

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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