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Kartogenin | Chondrocyte differentiation

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Price:
$159.00
Catalog #:
C5278-2s
Quantity:


Product Description

Kartogenin was shown to promote robust chondrocyte differentiation from primary human mesenchymal stem cells/MSCs [EC50 = 100 nM]. Kartogenin-induced chondrocytes from hMSCs express typical set of chondrogenic genes, form chondrocyte nodules, and exhibit characteristic chondrocyte functions. In an in vitro model mimicking cytokine-induced damage during osteoarthritis (OA), 1-5 µM of Kartogenin treatment inhibited nitric oxide (NO) and glycosaminoglycans (GAG) release. Direct Intra-articular (IA) administration of Kartogenin promoted cartilage repair in collagenase and surgery induced OA models in mice, and alleviated OA-induced joint pain. Mechanism of action studies showed that Kartogenin interacts with filamin A (FLNA) and results in the release of transcription factor CBFβ to the nucleus to regulate chondrogenic gene expression.


Technical information:

Chemical Formula:   C20H15NO3
CAS #:   4727-31-5
Molecular Weight:   317.34
Purity:   >98%
Appearance:   Off white solid
Chemical Name:   2-([1,1'-biphenyl]-4-ylcarbamoyl)benzoic acid
Solubility:   Up to 50 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Johnson K. et. al. A Stem Cell–Based Approach to Cartilage Repair. Science (2012) April 5. [Epub ahead of print].

Other Information:

Product Specification (pdf)
MSDS (pdf)

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