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Product Description
IWP-2 is one of the original Inhibitors of Wnt production compounds that targets Porcupine (Porcn), an acyltransferase catalyzing the palmitoylation lipidation of Wnt proteins [1]. IWP2 specifically inhibits Porcn acyltransferase activity and consequently blocks Wnt protein secretion and does not block general protein secretion of cellular responses mediated by the Hh and Notch proteins [2].
Technical information:
| Chemical Formula: | C22H18N4O2S3 | |
| CAS #: | 686770-61-6 | |
| Molecular Weight: | 466.6 | |
| Purity: | > 98% | |
| Appearance: | Off-white | |
| Chemical Name: | N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide | |
| Solubility: | Up to 5 mM in DMSO | |
| Synonyms: | 0 |
Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder or DMSO solution at -20oC desiccated.
Reference:
| 1. | Chen B, et al. Small moleculemediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol 2009; 5: 100107. Pubmed ID: 19125156 |
| 2. | Dodge ME, et al. Diverse Chemical Scaffolds Support Direct Inhibition of the Membrane-bound O-Acyltransferase Porcupine. J Biol Chem 2012; 287: 23246-23254 Pubmed ID: 22593577 |
Other Information:
Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.
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