XAV939 is a small molecule which selectively inhibits β-catenin-mediated transcription. It stimulates β-catenin degradation by stabilizing axin, the concentration-limiting component of the destruction complex. Using a quantitative chemical proteomic approach, XAV939 was found to stabilize axin by inhibiting the poly-ADP-ribosylating enzymes tankyrase 1 and tankyrase 2 with IC50 of 11 nM and 4 nM.
Technical information:
| Chemical Formula: | C14H11F3N2OS | |
| CAS #: | 284028-89-3 | |
| Molecular Weight: | 312.31 | |
| Purity: | >98% | |
| Appearance: | White solid | |
| Chemical Name: | 2-(4-(trifluoromethyl)phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol | |
| Solubility: | Up to 50 mM in DMSO |
Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.
Reference:
| 1. | Tankyrase inhibition stabilizes axin and antagonizes Wnt signaling; Shih-Min A. Huang et al. Nature (2009) 461, 614-620 |
| 2. | Hedin, L. et al. Forskolin effects on the cAMP system and steroidogenesis in the immature rat ovary. Mol Cell Endocrinol (1983) 33: 69-80. |
Other Information:
Product Specification (pdf)
MSDS (pdf)
