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Pirarubicin | DNA intercalator

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Product Description

Pirarubicin is an anthracycline drug used to treat various types of cancer. It intercalates between base pairs and interacts with topoisomerase II, therefore inhibiting DNA replication and repair and RNA synthesis. Compared with its analog Adriamycin (Doxorubicin), Pirarubicin is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines. (1,2)

Technical information:

Chemical Formula:   C32H37NO12
CAS #:   72496-41-4
Molecular Weight:   627.64
Purity:   > 98%
Appearance:   orange red
Chemical Name:  


Solubility:   Up to 100 mM in DMSO
Synonyms:   0

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


1. Hirano S et al., Comparison of cardiotoxicity of pirarubicin, epirubicin and doxorubicin in the rat. Drugs Exp Clin Res. 1994, 20(4):153-60. Pubmed ID: 7813387
2. Schott B and Robert J., Comparative cytotoxicity, DNA synthesis inhibition and drug incorporation of eight anthracyclines in a model of doxorubicin-sensitive and -resistant rat glioblastoma cells. Biochem Pharmacol. 1989, 38(1):167-72. Pubmed ID: 2910297

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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